主权项 |
1. A method for diagnosing Alzheimer's disease in a subject, comprising:
determining the protein expression of a plurality of proteins comprising at least F13A1, PON1, ITIH1, CLU, APOD, GSN, and APOA4 from a biological sample from the subject; comparing the protein expression from step (a) to the protein expression of a plurality of proteins comprising at least F13A1, PON1, ITIH1, CLU, APOD, GSN, and APOA4 from a control biological sample, wherein the control biological sample is obtained from a subject with cognitive impairment due to the normal effects of aging or with no cognitive impairment; diagnosing Alzheimer's disease in the subject based on the differential protein expression of the plurality of proteins between the subject biological sample and the control biological sample, wherein the subject is diagnosed with Alzheimer's disease if the differential protein expression has a statistical p value of 0.05 or below. |