发明名称 ALZHEIMER'S DISEASE DIAGNOSTIC PANELS AND METHODS FOR THEIR USE
摘要 Novel compositions, methods, assays and kits directed to a diagnostic panel for Alzheimer's disease are provided. In one embodiment, the diagnostic panel includes one or more proteins associated with Alzheimer's disease.
申请公布号 US2015198618(A1) 申请公布日期 2015.07.16
申请号 US201514672908 申请日期 2015.03.30
申请人 Integrated Diagnostics, Inc. 发明人 Li Xiao-Jun;Kearney Paul Edward
分类号 G01N33/68 主分类号 G01N33/68
代理机构 代理人
主权项 1. A method for diagnosing Alzheimer's disease in a subject, comprising: determining the protein expression of a plurality of proteins comprising at least F13A1, PON1, ITIH1, CLU, APOD, GSN, and APOA4 from a biological sample from the subject; comparing the protein expression from step (a) to the protein expression of a plurality of proteins comprising at least F13A1, PON1, ITIH1, CLU, APOD, GSN, and APOA4 from a control biological sample, wherein the control biological sample is obtained from a subject with cognitive impairment due to the normal effects of aging or with no cognitive impairment; diagnosing Alzheimer's disease in the subject based on the differential protein expression of the plurality of proteins between the subject biological sample and the control biological sample, wherein the subject is diagnosed with Alzheimer's disease if the differential protein expression has a statistical p value of 0.05 or below.
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