Multi-Layer Drug Delivery System

摘要

The present disclosure pertains to a construction consisting of in the order from the outside towards the inside: an occlusive or non-occlusive backing substrate; a drug-loaded layer including a therapeutic concentration of at least one or a combination of cosmetic and/or pharmaceutical active ingredients; a permeable or semi-permeable support substrate; a non-drug loaded cured silicone gel adhesive layer cured onto the permeable or semi-permeable support substrate; and a temporary release liner configured to protect the cured silicone gel adhesive layer.

主权项

1. A multi-layer delivery system, comprising:
an occlusive or non-occlusive backing substrate; a drug-loaded layer including a therapeutic concentration of at least one or a combination of cosmetic and/or pharmaceutical active ingredients; a permeable or semi-permeable support substrate; a non-drug loaded silicone gel adhesive layer obtained by (i) reacting a gel producing composition comprising (A) at least one alkenyl-substituted polydiorganosiloxane, (B) at least one organosiloxane containing silicone-bonded hydrogen atoms, and (C) at least one catalyst for the reaction of the SiH groups with the Si-alkenyl groups; and (ii) curing the product of (i); the non-drug loaded silicone gel adhesive layer is then cured onto the permeable or semi-permeable support substrate; and a temporary release liner configured to protect the cured silicone gel adhesive layer.