| 摘要 |
PROBLEM TO BE SOLVED: To provide compositions and methods for enhancing repair of damaged DNA in skin cells.SOLUTION: Topical compositions of the invention comprises at least one agent that up-regulates circadian gene expression in skin cells and at least one non-circadian agent that delays mitosis in skin cells. Preferably, the compositions comprise one or more keratinocyte clock and per1 gene activators, along with SIRT1 or one or more sirt1 activators. More preferably, the sirt1 activator is a synergistic combination of a specific peptidic sirt1 activators and resveratrol. Preferably, the composition is easy to use, effective, cosmetically acceptable, chemically, thermodynamically and light stable, safe for topical use, with little or no side effects, and commercially feasible in a personal care marketplace. |
