Systems and Methods for Treating an Opioid-Induced Adverse Pharmacodynamic Response

摘要

Disclosed in certain embodiments is a method of treating or preventing an opioid-induced adverse pharmacodynamic response comprising administering to a patient in need thereof an effective amount of buprenorphine.

主权项

1. A method of treating pain comprising orally co-administering to a patient in need thereof (i) an oral dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof and (ii) an effective amount of buprenorphine to prevent or treat an adverse pharmacodynamic response induced by the administration of the hydrocodone or pharmaceutically acceptable salt thereof, wherein the adverse pharmacodynamic response is selected from the group consisting of bowel dysfunction, respiratory depression and a combination thereof and wherein the co-administration is analgesically effective.