| 摘要 |
PROBLEM TO BE SOLVED: To provide PRG4 protein which is an oral care composition for improving oral cavity boundary lubrication, and to provide methods for using a therapeutic modulation thereof.SOLUTION: The invention relates to compositions and methods for using PRG4 and therapeutic modulation thereof, including, use as a surgical lubricant, use in a treatment for prevention or reduction of post-surgical adhesions, use in a treatment for oral ulcerations, use as an athletic lubricating patch, use as a dermal filler, use in a treatment for dry mouth, use in a drug delivery method or composition, and use in nursing lubrication. The oral care composition has the concentration of the PRG4 of 10-10,000 μg/mL, and/or an average molar mass of 50 kDa-400 kDa. |
