| 摘要 |
<p>(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization IN International Bureau (10) International Publication Number (43) International Publication Date 30 September 2010 (30.09.2010) PCT W O 2010/111595 A3 (51) International Patent Classification: 02108 (US). DALY, Mark [-/US]; Boston, Mas C12Q 1/68 (2006.01) G01N 33/53 (2006.01) sachusetts (US). C12N 15/12 (2006.01) (74) Agents: GARVEY, John M. et al.; FOLEY & LARD (21) International Application Number: NER LLP, 111 Huntington Avenue, Boston, Mas PCT/US2010/028834 sachusetts 02199 (US). (22) International Filing Date: (81) Designated States (unless otherwise indicated, for every 26 March 2010 (26.03.2010) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, (25) Filing Language: English CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, (26) Publication Language: English DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (30) Priority Data: KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, 61/164,245 27 March 2009 (27.03.2009) US ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, 61/317,498 25 March 2010 (25.03.2010) US NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, (71) Applicant (for all designated States except US): TUFTS SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, - NEW ENGLAND MEDICAL CENTER [US/US]; TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 750 Washington Street, NEMC Box 817, Boston, Mas- (84) Designated States (unless otherwise indicated, for every sachusetts 02111 (US). kind of regional protection available): ARIPO (BW, GH, (72) Inventors; and GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, (75) Inventors/Applicants (for US only): SEDDON, Johanna ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, M. [US/US]; 4 Louisburg Square, Boston, Massachusetts TM), European (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, [Continued on next page] (54) Title: MARKERS RELATED TO AGE-RELATED MACULAR DEGENERATION AND USES THEREFOR (57) Abstract: Described herein are compositions, kits and 3 5 -methods for diagnosing and tracking the progression of AMD in a subject by detecting the presence or absence of particular - lipid metabolism markers associated with AMD. Predictive computer models of disease risk are also disclosed. - --- ~----- ---------- -- ... CNV FREUENCY W O 2 0 10 /1 1 1 5 9 5 A 3 ||1llll|||1ll 11||1lllllllllllll|||||||||||||||||||||||||||||||||||||||||||||||||| MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, - before the expiration of the time limit for amending the TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, claims and to be republished in the event of receipt of ML, MR, NE, SN, TD, TG). amendments (Rule 48.2(h)) Published: (88) Date of publication of the international search report: - with international search report (Art. 21(3)) 21 April 2011</p> |
