| 发明名称 |
(R)-N-METHYLNALTREXONE, PROCESSES FOR ITS SYNTHESIS AND ITS PHARMACEUTICAL USE |
| 摘要 |
PROBLEM TO BE SOLVED: To provide stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX and intermediates thereof and methods for their use.SOLUTION: A composition comprises R-MNTX, and is free of HPLC detectable S-MNTX at a detection limit of 0.02% and at a quantitation limit of 0.05%. |
| 申请公布号 |
JP2015129190(A) |
申请公布日期 |
2015.07.16 |
| 申请号 |
JP20150077909 |
申请日期 |
2015.04.06 |
| 申请人 |
PROGENICS PHARMACEUTICALS INC |
发明人 |
DOSHAN HAROLD D;PEREZ JULIO |
| 分类号 |
A61K31/485;A61K31/40;A61K31/4468;A61K31/451;A61K45/00;A61P1/04;A61P1/10;A61P1/18;A61P3/02;A61P5/04;A61P7/06;A61P7/08;A61P15/00;A61P19/02;A61P21/00;A61P25/00;A61P25/06;A61P25/20;A61P25/36;A61P29/00;A61P29/02;A61P31/14;A61P31/18;A61P35/00;C07D489/08 |
主分类号 |
A61K31/485 |
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