| 发明名称 |
VACCINE AGAINST RSV |
| 摘要 |
Provided is a vaccine against respiratory syncytial virus (RSV), comprising a recombinant human adenovirus of serotype 26 that comprises nucleic acid molecule encoding a RSV F protein or immunologically active part thereof. |
| 申请公布号 |
US2015196632(A1) |
申请公布日期 |
2015.07.16 |
| 申请号 |
US201514675189 |
申请日期 |
2015.03.31 |
| 申请人 |
Crucell Holland B.V. |
发明人 |
Radosevic Katarina;Custers Jerome H.;Vellinga Jort;Widjojoatmodjo Myra N. |
| 分类号 |
A61K39/155;C12N7/00;A61K9/00 |
主分类号 |
A61K39/155 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition for vaccinating a subject against respiratory syncytial virus (RSV) F protein, composition comprising:
a recombinant human adenovirus of serotype 26 that comprises a nucleic acid molecule encoding an RSV F protein or a fragment of an RSV F protein, which composition, upon a single intramuscular injection to a Cotton rat (Sigmodon hispidus), gives complete protection against RSV challenge replication in a Cotton rat model of respiratory viral infection. |
| 地址 |
Leiden NL |
