发明名称 |
CHEMICALLY AND THERMODYNAMICALLY STABLE INSULIN ANALOGUES AND IMPROVED METHODS FOR THEIR PRODUCTION |
摘要 |
The subject matter of this invention is directed towards chemically and thermodynamically stable single-chain insulin (SCI) analogues that are resistant to deamidation and fibrillation. The invention further discloses improved methods for the recombinant expression, purification and refolding of SCI. |
申请公布号 |
EP2768520(A4) |
申请公布日期 |
2015.07.15 |
申请号 |
EP20120841547 |
申请日期 |
2012.10.16 |
申请人 |
AMIDEBIO LLC |
发明人 |
STOWELL, MICHAEL. H.B.;PLAM, MIKHAIL |
分类号 |
A61K38/28;A61P3/10;A61P7/12;C07K14/62 |
主分类号 |
A61K38/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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