发明名称 |
HETEROCYCLIC INHIBITORS OF ERK2 AND USES THEREOF |
摘要 |
<p>Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein Z1 and Z2 are each independently nitrogen or CH and Ring A, TmR1, QR2, UnR3, and Sp are as described in the specification. The compounds are especially useful as inhibitors of ERK2 and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.</p> |
申请公布号 |
EP1363906(B1) |
申请公布日期 |
2015.07.15 |
申请号 |
EP20020724922 |
申请日期 |
2002.02.08 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
CAO, JINGRONG;GREEN, JEREMY;HALE, MICHAEL;MALTAIS, FRANCOIS;STRAUB, JUDY;TANG, QING;ARONOV, ALEX |
分类号 |
C07D403/04;A61K31/506;A61K31/517;A61K31/5377;A61K31/551;A61P1/16;A61P3/10;A61P5/00;A61P7/02;A61P9/08;A61P9/10;A61P17/06;A61P19/00;A61P25/00;A61P25/28;A61P29/00;A61P31/04;A61P31/12;A61P35/00;A61P37/06;A61P37/08;A61P43/00;C07D401/14;C07D403/14;C07D405/14;C07D413/14 |
主分类号 |
C07D403/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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