发明名称 |
METHODS AND COMPOUNDS FOR PREVENTING, TREATING AND DIAGNOSING AN INFLAMMATORY CONDITION |
摘要 |
Provided is an antibody with a specificity to an epitope that is a region corresponding to amino acid positions 63-79 or 73-85 of the human protein S100A9. Provided is further an antibody with a specificity to an epitope that is a region corresponding to amino acid positions 55-71 of the human protein S100A8. Provided is further the use of such antibody in the treatment or diagnosis of an inflammatory disorder. Also provided is an in-vitro method of identifying a compound capable of inhibiting the formation of a complex between a peptide corresponding to one of the above epitopes of S100A9 or the above epitope of S100A8 and a TLR4 receptor, where a compound suspected to affect the complex formation is contacted with the peptide and the TLR4 receptor. Further provided is an in-vitro method of identifying a compound capable of increasing the stability of a complex between a S100A8 protein and a S100A9 protein, where the two proteins are contacted in the presence of a compound suspected to affect the complex formation. |
申请公布号 |
EP2892922(A2) |
申请公布日期 |
2015.07.15 |
申请号 |
EP20130776425 |
申请日期 |
2013.09.10 |
申请人 |
WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTER |
发明人 |
ROTH, JOHANNES;VOGL, THOMAS PD. |
分类号 |
C07K16/24;A61P35/00;A61P37/00;C07K14/52 |
主分类号 |
C07K16/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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