发明名称 |
TARGETING THE TUMOR MICROENVIRONMENT USING MANIPULATED NKT CELLS |
摘要 |
The present invention regards methods and/or compositions related to Natural Killer T cells that are engineered to harbor an expression construct that encodes IL-2, IL-4, IL-7, and/or IL-15 and additionally or alternatively comprise a chimeric antigen receptor (CAR). In specific embodiments, the CAR is a CAR that targets the GD2 antigen, for example in neuroblastoma. |
申请公布号 |
EP2755487(A4) |
申请公布日期 |
2015.07.15 |
申请号 |
EP20120831178 |
申请日期 |
2012.09.14 |
申请人 |
BAYLOR COLLEGE OF MEDICINE |
发明人 |
METELITSA, LEONID, S.;LIU, DAOFENG;DOTTI, GIANPIETRO;HECZEY, ANDRAS |
分类号 |
A01N63/00;A61K39/00;C12N5/0783 |
主分类号 |
A01N63/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|