发明名称 |
NOVEL CELLOBIOHYDROLASE ENZYMES |
摘要 |
Provided are isolated cellobiohydrolases comprising a modified Glycoside Hydrolase (GH) Family 7 catalytic domain, a GH Family 7 catalytic domain and a modified Family 1 carbohydrate binding module (CBM), or both a modified Family 7 catalytic domain and a modified Family 1 CBM. Such isolated cellobiohydrolases exhibit from 45% to about 99.9% amino acid sequence identity to amino acids 1-436 of SEQ ID NO: 1 or to amino acids 1-438 of SEQ ID NO: 2 and improved activity on process substrates. Also provided are genetic constructs and genetically modified microbes for expressing the isolated cellobiohydrolases, a process for producing the isolated cellobiohydrolases, cellulase enzyme mixtures comprising the isolated cellobiohydrolase and a process for hydrolyzing a cellulosic substrate with such cellulase enzyme mixtures. |
申请公布号 |
EP2751265(A4) |
申请公布日期 |
2015.07.15 |
申请号 |
EP20120827897 |
申请日期 |
2012.08.29 |
申请人 |
IOGEN ENERGY CORPORATION |
发明人 |
MONTALIBET, JACQUELINE;GUDYNAITE-SAVITCH, LORETA;HILL, CHRISTOPHER;HINDLE, CHRISTOPHER D.;LAVIGNE, JAMES A.;MASRI, NABIL;TAHNA, FUAD;TOMASHEK, JOHN J. |
分类号 |
C12N9/42;C12N1/14;C12N1/15;C12N1/19;C12N15/59;C12N15/80 |
主分类号 |
C12N9/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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