Biochip

摘要

A biochip including a metal nanoparticle layer on a multilayer substrate can perform qualitative and quantitative analyses simply without a separate tag. A biochip including a metal nanoparticle layer on a multilayer substrate and using a CMOS image sensor can be an economically beneficial biochip reusable and convenient in use by employing a relatively simple detection method without a need of using a separate tag.

主权项

1. A biochip comprising:
a multilayer comprising a substrate, an indium nanoparticle layer deposited on the substrate, a dielectric layer deposited on the indium nanoparticle layer in the substrate, and a charging layer deposited on a portion of the indium nanoparticle layer deprived of the dielectric layer; and a CMOS image sensor; wherein the indium nanoparticle layer is 10 to 20 nm in thickness; and wherein the dielectric layer is configured to cause an analyte without a tag to bind to the dielectric layer, and in response to the bound analyte without a tag the CMOS image sensor can measure a change in light intensity and provide a signal representative of detected analyte without a tag.