发明名称 |
ANTIBACTERIAL AND ANTIVIRAL PEPTIDES FROM ACTINOMADURA NAMIBIENSIS |
摘要 |
<p>The invention refers to of a compound of the formula (I) wherein R3 and R4 are independently H or OH, and wherein m and n are independently of one another 0, 1 or 2, obtainable from Actinomadura namibiensis (DSM 6313), its use for the treatment of bacterial infections, viral infections and/or pain, and pharmaceutical composition comprising it. The compounds of formula (I) have been defined as labyrinthopeptins and consist of a highly bridged peptidic structure of 18 amino acids containing lanthionine-like residues and alpha disubstituted amino acid analogues. The amino acid sequence is XDWXLWEXCXTGXLFAXC, wherein the two Cys residues form a disulfide bridge and each X independently represents one of the non-natural amino acids involved in the bridging linkages.</p> |
申请公布号 |
CA2665269(C) |
申请公布日期 |
2015.07.14 |
申请号 |
CA20072665269 |
申请日期 |
2007.09.25 |
申请人 |
SANOFI-AVENTIS |
发明人 |
SEIBERT, GERHARD;VERTESY, LASZLO;WINK, JOACHIM;WINKLER, IRVIN;SUSSMUTH, RODERICH;SHELDRICK, GEORGE;MEINDL, KATHRIN;BROENSTRUP, MARK;HOFFMANN, HOLGER;GUEHRING, HANS;TOTI, LUIGI |
分类号 |
C07K7/08;A61K38/10;A61P31/04;A61P31/12;C07K14/36;C12P21/04 |
主分类号 |
C07K7/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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