Anti-staphylococcal celecoxib derivatives

摘要

A method of treating infection by Staphylococcus in a subject by administering a pharmaceutical composition including a celecoxib derivative of formula I or a;
pharmaceutically acceptable salt thereof is described.

The preparation of numerous celecoxib derivatives for testing as potential anti-staphylococcal agents is also described.

主权项

1. A method of treating infection by Staphylococcus in a subject, comprising administering to the subject a pharmaceutical composition including a compound of formula I or a pharmaceutically acceptable salt thereof:wherein R1 is selected from carboxamide, sulfonamide, amino, aminosulfonamide, and acylamido groups, and R2 is selected from aryl, aralkyl, fused aryl groups, and fused heteroaryl groups.