Compounds as histamine H3 receptor ligands

摘要

The present invention relates to novel compounds of formula (I), and their pharmaceutically acceptable salts and compositions containing them.;;The present invention also relates to a process for the preparation of above compounds of formula (I), and their pharmaceutically acceptable salts.;The compounds of formula (I) are useful in the treatment of various disorders that are related to Histamine H3 receptors.

主权项

1. A compound of the general formula (I):wherein,
at each occurrence, R1 is independently selected from hydrogen, hydroxy, hydroxyalkyl, halogen, alkyl, alkoxy, haloalkyl, haloalkoxy, cyano or —C(O)—NH2; L is alkyl or X is C, O or N—R2; Y is C or N; A is —C(O)— or —CH2; R2 is hydrogen, alkyl, —C(O)-alkyl or —S(O)2-alkyl; “r” is 0 or 1; “p” is an integer ranging from 0 to 3;or a pharmaceutically acceptable salt thereof.