Magnetic cells for localizing delivery and tissue repair

摘要

Normal or genetically modified cell(s) having magnetic nanoparticle(s) bound (affixed) to their surfaces and methods of delivery to target tissues, e.g. for treatment of disease and or injury.

主权项

1. A method of delivering a cell to a target tissue in an animal, said method comprising,
(a) affixing, binding, or attaching at least one magnetic nanoparticle to the surface of said cell to obtain a magnetic particle-comprising cell, wherein the at least one magnetic nanoparticle is affixed to the cell surface by a cell-surface specific binding agent, by a covalent bond, or by a surface coating on the at least one magnetic nanoparticle comprising one or more antibodies, antibody fragments, proteins or sugar fragments that bind to said cells; (b) administering said magnetic particle-comprising cell to the target tissue of the animal; (c) applying a magnetic field to said target tissue such that said magnetic particle comprising cell is delivered to specific regions of said target tissue; and (d) maintaining said magnetic field over said target tissue to cause said cell to remain at the target tissue until the cell becomes affixed to the target tissue, wherein the cell is an ocular cell or optic nerve cell and the target tissue is eye tissue.