发明名称 |
Compositions comprising spicamycin derivatives and methods of use thereof |
摘要 |
The present invention relates to compositions comprising spicamycin derivatives, methods of making such compositions, and their use in the treatment and/or prevention of pain, including neuropathic pain. |
申请公布号 |
US9078910(B2) |
申请公布日期 |
2015.07.14 |
申请号 |
US201313962279 |
申请日期 |
2013.08.08 |
申请人 |
DARA BIOSCIENCES, INC. |
发明人 |
Radomsky Michael;Delmedico Mary Katherine;Jett Linda |
分类号 |
A01N43/04;A61K31/70;A61K31/7076;A61K9/00;A61K45/06;A61K47/10 |
主分类号 |
A01N43/04 |
代理机构 |
Alston & Bird LLP |
代理人 |
Alston & Bird LLP |
主权项 |
1. A composition comprising:
a) a spicamycin derivative of Formula II:wherein R1 and R2 are different from each other and represent H or OH, and R represents a substituted or unsubstituted alkyl, alkenyl, alkynyl, or cycloalkyl;
b) a biocompatible alcohol that solubilizes said spicamycin derivative; c) glycerin or a glycol that is miscible with said biocompatible alcohol and solubilizes said spicamycin derivative; and d) a surfactant soluble in a mixture of said biocompatible alcohol and said glycerin or glycol;wherein said composition is essentially free of mono-ethanolamine, and wherein said composition is a single-phase solution. |
地址 |
Raleigh NC US |