发明名称 |
Inositol pyrophosphates, and methods of use thereof |
摘要 |
The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphospahte (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells. |
申请公布号 |
US9078908(B2) |
申请公布日期 |
2015.07.14 |
申请号 |
US201313923023 |
申请日期 |
2013.06.20 |
申请人 |
NormOxys, Inc. |
发明人 |
Nicolau Yves Claude;Lehn Jean-Marie;Fylaktakidou Konstantina C.;Greferath Ruth |
分类号 |
A61K31/66;A61K31/70;A61K35/18;C07F9/117;A61K31/6615;A61K31/715;C07F9/6574;C07H15/207;C12N5/078 |
主分类号 |
A61K31/66 |
代理机构 |
Morgan, Lewis & Bockius LLP |
代理人 |
Morgan, Lewis & Bockius LLP |
主权项 |
1. A method of treating a mammal undergoing radiation therapy of cancer, comprising administering to the mammal a therapeutically effective amount of a composition comprising a compound represented by Formula I:
nC⊕ An⊖ Iwherein:
C+ represents independently for each occurrence an aliphatic ammonium cation, an alkali metal cation, an alkaline earth cation, or other suitable metal cation; An− represents an inositol hexaphosphate comprising 1, 2, or 3 internal pyrophosphate rings or an acyl group; and n is an integer in the range of 1 to 10 inclusive. |
地址 |
Boston MA US |