| 发明名称 | Method for treating ocular cancer | ||
| 摘要 | It has now been found that the p53 pathway is inactivated in ocular cancers such as retinoblastoma. As such, the present invention is a method for inducing ocular cancer cell death using a p53 activator. In particular embodiments, the p53 activator blocks the interaction between DM2 or DMX and p53. As the p53 activator induces ocular cancer cell death, a method for preventing or treating ocular cancer is also provided. | ||
| 申请公布号 | US9078895(B2) | 申请公布日期 | 2015.07.14 |
| 申请号 | US201314097746 | 申请日期 | 2013.12.05 |
| 申请人 | St. Jude Children's Research Hospital;Flanders Interuniversity Institute for Biotechnology;Universiteit Gent;Leiden University Medical Center | 发明人 | Dyer Michael A.;Marine Jean-Christophe;Jochemsen Aart Gerrit |
| 分类号 | A61K31/496;A61K31/00;G01N33/574;A61K31/473 | 主分类号 | A61K31/496 |
| 代理机构 | Licata & Tyrrell P.C. | 代理人 | Licata & Tyrrell P.C. |
| 主权项 | 1. A method for inducing ocular cancer cell death comprising contacting an ocular cancer cell with an effective amount of a p53 activator that blocks an interaction between p53 and DM2 or p53 and DMX thereby inducing apoptosis in the ocular cancer cell. | ||
| 地址 | Memphis TN US | ||