Diagnostic test for inflammatory endothelial dysfunctions in pregnancies

摘要

The present invention relates to a diagnostic test for inflammatory endothelial dysfunctions in pregnant women. Particularly, the present invention relates to a method of diagnosing or evaluating the risk of contracting an inflammatory endothelial dysfunction of the maternal compartment comprising the following steps: a) detecting the plasma levels of long pentraxin PTX3 in blood samples taken from a pregnant woman; b) comparing the PTX3 plasma level data, obtained according to step a), with statistically significant PTX3 plasma level data of normal pregnant population.

主权项

1. Method of diagnosing or evaluating a risk of contracting an inflammatory endothelial dysfunction of a maternal compartment, said dysfunction being preeclampsia and/or eclampsia, the method comprising the steps of:
obtaining a blood plasma sample from a pregnant woman in a third trimester of pregnancy; contacting the blood plasma sample with rat monoclonal anti-PTX3 antibody (mAb) MNB4, and then detecting an amount of long pentraxin PTX3 bound to the anti-PTX3 MNB4 monoclonal antibody to indicate a level of long pentraxin PTX3 in the blood plasma sample; and determining whether plasma level of long pentraxin PTX3 in the blood plasma sample taken from the pregnant woman in the third trimester of pregnancy is above about 3 ng/ml, wherein a level of long pentraxin PTX3 above 3 ng/ml in the blood plasma sample from the pregnant woman indicates that the woman has an increased risk of preeclampsia or eclampsia.