α-Lipoic acid nanoparticles and methods for preparing thereof

摘要

Provision of a stable α-lipoic acid. A method for producing α-lipoic acid nanoparticles, the method comprising the steps of: preparing an aqueous dispersion liquid containing α-lipoic acid and a nonionic surfactant; adding a divalent metal salt into the aqueous dispersion liquid, wherein the divalent metal salt is a divalent metal halide, a divalent metal acetate or a divalent metal gluconate; and adding an alkali metal carbonate or an alkali metal phosphate into the aqueous dispersion liquid which has been added with the divalent metal salt, thereby forming α-lipoic acid nanoparticles.

主权项

1. α-Lipoic acid nanoparticles comprising α-lipoic acid, a nonionic surfactant, a divalent metal ion, and a carbonate ion or a phosphate ion, wherein the divalent metal ion is a calcium ion, a zinc ion or a magnesium ion, wherein mixed micelles of the α-lipoic acid and the nonionic surfactant are formed, and wherein a coating of a polyvalent metal inorganic salt is formed at the micelle surface.