| 主权项 |
1. A compound of Formula (I) or a stereoisomeric form thereof, wherein Het1 is a heterocycle, having formula (a-1), (a-2), (a-3), or (a-4) R3 is C1-4alkyl; R4, R5, R6, and R8 each independently are hydrogen or C1-4alkyl optionally substituted with one or more halo substituents; R7a is hydrogen, halo, or C1-4alkyl; R7b and R7c each independently are hydrogen, halo, cyano, C1-4alkyloxy, cycloC3-7alkyl, or C1-4alkyl optionally substituted with one or more halo substituents; Xa is CH or N; Xb is O or S; A1 is CR9; wherein R9 is hydrogen, halo, or C1-4alkyloxy; A2 is CH; and A3 and A4 are CH; L1 is O, carbonyl, NR10, NH—(C═O), or (C═O)—NH; wherein R10 is hydrogen or C1-4alkyl; R1 is cycloC3-7alkyl; C2-6alkenyl; or C1-6alkyl optionally substituted with one or more substituents each independently selected from the group consisting of halo, cyano, 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, NR11aR12a, cycloC3-7alkyl, and C1-6alkyloxy;
wherein each cycloC3-7alkyl may be substituted with one or more substituents each independently selected from the group consisting of halo, C1-4alkyloxy, cyano, and C1-4alkyl optionally substituted with one or more halo substituents; L2 represents a direct bond; carbonyl; O; S; S(═O)p; NR13a; NR13b—C1-3alkanediyl; C1-3alkanediyl-NR13c; C1-3alkanediyl optionally substituted with one or more halo substituents; or C1-3alkanediyl wherein two geminal hydrogen atoms may be replaced by C2-6alkanediyl; p represents 1 or 2; R2 is pyrrolidinyl; tetrahydrofuranyl; piperidinyl; tetrahydropyranyl; morpholinyl; piperazinyl; cycloC3-7alkyl; hexahydro-1H-1,4-diazepin-1-yl; 1,3-dihydro-2H-isoindol-2-yl; 2,3-dihydro-1H-indol-1-yl; 3,4-dihydro-1(2H)-quinolinyl; 3,4-dihydro-2(1H)-isoquinolinyl; 1,2-dihydropyridinyl; indanyl; 1,3-benzodioxolyl; or Ar;
wherein pyrrolidinyl, tetrahydrofuranyl, piperidinyl, tetrahydropyranyl, morpholinyl, piperazinyl, cycloC3-7alkyl, hexahydro-1H-1,4-diazepin-1-yl, 1,3-dihydro-2H-isoindol-2-yl, 2,3-dihydro-1H-indol-1-yl, 3,4-dihydro-1(2H)-quinolinyl, 3,4-dihydro-2(1H)-isoquinolinyl, 1,2-dihydropyridinyl, indanyl and 1,3-benzodioxolyl may be substituted with one or more substituents each independently selected from the group consisting of C2-6alkenyl, cycloC3-7alkyl,
C1-4alkylcarbonyl, hydroxyl, oxo, halo, C1-4alkyloxy, C1-4alkyloxyC1-4alkyl, C1-4alkyloxycarbonyl, Ar, and C1-4alkyl optionally substituted with one or more halo substituents;wherein each Ar independently is phenyl optionally substituted with one or more substituents each independently selected from the group consisting of halo, C1-4alkyloxy, cyano, NR11bR12b, morpholinyl
C1-4alkyloxy substituted with one or more halo substituents,and C1-4alkyl optionally substituted with one or more halo substituents;or a 5- or 6-membered heteroaryl selected from the group consisting of furanyl, thiophenyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, thiadiazolyl, oxadiazolyl, pyridinyl, pyrimidinyl, pyridazinyl, and pyrazinyl,wherein said 5- or 6-membered heteroaryl may be substituted with one or more substituents each independently selected from the group consisting of halo, C1-4alkyloxy, cyano, NR11cR12c, morpholinyl, and C1-4alkyl optionally substituted with one or more halo substituents; each R11a, R11b and R11c independently is hydrogen, C1-4alkyl or C1-4alkylcarbonyl; each R12a, R12b and R12C independently is hydrogen or C1-4alkyl; each R13a, R13b and R13c independently is hydrogen, or C1-4alkyl optionally substituted with one or more substituents each independently selected from the group consisting of halo and cycloC3-7alkyl; or a pharmaceutically acceptable addition salt or a solvate thereof. |
