Derivados de tio-2-amino-quinolina-6-substituída úteis como inibidores da beta-secretase (bace)

摘要

The present invention is directed to 6-substituted-thio-2-amino-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD), mild cognitive impairment, senility and/or dementia. The compounds of the present invention are inhibitors ofβ-secretase, also known asβ-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2.