Devices and methods for noninvasive measurement of intracranial pressure

摘要

Provided are systems and methods for noninvasively assessing intracranial pressure by controllably applanating at least a portion of a subject's ocular globe so as to collapse an intraocular blood vessel and correlating the collapse pressure to intracranial pressure. Also provided are ophthalmic components useful in ophthalmic imaging applications, as well as methods of assessing intracranial pressure that are based, at least in part, on the degree of papilledema, if any, present in the subject.

主权项

1. A system for measuring intracranial pressure in a subject, comprising:
an applanator configured to controllably at least partially applanate a portion of a subject's ocular globe; an ophthalmic component configured to engage with the applanator; a first image collector configured to collect light reflected from an intraocular blood vessel of the subject; an illumination train configured to direct light through the ophthalmic component to the intraocular blood vessel of the subject and to direct light reflected from the intraocular blood vessel to the first image collector, wherein the illumination train is further configured to direct illumination reflected from an interface between the ophthalmic component and an applanated region of the subject's ocular globe, wherein a portion of the illumination passes through a contacted portion of the interface and a portion of the illumination reflects off the interface; and a processor configured to estimate an intracranial pressure of the subject based on illumination reflected from the at least partially applanated portion of the subject's ocular globe and illumination reflected from the intraocular blood vessel of the subject.