Method for producing a drug delivery system on the basis of polyelectrolyte complexes

摘要

A method that relates to the fields of polymer chemistry, pharmacy and medicine and releases drugs as a component of implants into the environment of the implant. A method that, in a simple and easily reproducible manner, generates a drug delivery system, which releases drugs in a locally targeted and controllably delayed manner. Polyanions and polycations are mixed in a liquid in a non-stoichiometric ratio, relative to the charged monomer units, wherein drugs are added to the polyelectrolytes either before, during or after the mixing, or charge-carrying drugs and an oppositely charged polyelectrolyte are mixed, and after the mixing the polyelectrolyte complex produced is applied to the surface of a medical structure or material or is positioned on the surface directly at the location where the drug is to be released.

主权项

1. A method for producing a drug delivery system on the basis of polyelectrolyte complexes, comprising:
producing a polyelectrolyte complex by one of:
mixing polyelectrolytes comprising polyanions and polycations in a liquid in a non-stoichiometric ratio relative to charged monomer units, and adding at least one drug to the polyelectrolytes one of before, during and after the mixing; andmixing at least one charge-carrying drug and an oppositely charged polyelectrolyte, comprising polyanions or polycations in liquid; and applying a layer of the polyelectrolyte complex to a surface or a surface region of a medical structure or material, wherein a liquid component of the applied polyelectrolyte complex layer is removed by lowering the pressure.