| 主权项 |
1. A method of treating a mammalian cell proliferative disorder comprising administering a therapeutically effective amount of a compound of the structure (I):wherein:
R1 to R3 are each independently —H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, cycloalkyl, substituted cycloalkyl, alkoxy, substituted alkoxy, thioalkyl, substituted thioalkyl, hydroxy, halogen, amino, amido, carboxyl, —C(O)H, acyl, oxyacyl, carbamate, sulfonamide or sulfuryl; each R4 is independently alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl; E1 to E4 are each independently —O, —NR5, or —S, wherein R5 is —H or C1-C6alkyl 1; X is 0 to 8; and an additional anti-neoplastic agent, wherein the cancer is selected from the group consisting of mammary cancer, small-cell lung cancer, non-small-cell lung cancer, colorectal cancer, leukemia, melanoma, pancreatic adenocarcinoma cancer, central nervous system (CNS) cancer, ovarian cancer, prostate cancer, sarcoma cell of soft tissue, sarcoma cell of bone, head cancer, neck cancer, gastric cancer, thyroid cancer, stomach cancer, myeloma, bladder cancer, renal cancer, neuroendocrine cancer, non-Hodgkin's disease and Hodgkin's disease. |
