Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject

摘要

A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes one or more substrates configured to contact one or more body contours in proximity to one or more joints of articulating bone of a mammalian subject; one or more sensors configured to detect one or more physiological conditions of the one or more joints; and one or more microjet applicators supported by the one or more substrates and configured to respond to the one or more sensors by injecting one or more medicaments to the one or more joint tissues of the mammalian subject.

主权项

1. A device comprising:
one or more substrates configured to contact one or more body contours at one or more joints of articulating bone of a mammalian subject; one or more microjet applicators supported by the one or more substrates and substantially localized and substantially aligned in reference to the one or more joints, the one or more microjet applicators configured to inject one or more medicaments to the one or more joint tissues of the mammalian subject; and one or more sensors supported by the one or more substrates, the one or more sensors configured to monitor, in real time, frequency of joint use and level of effort used by the one or more joints; a computing device including a detector configured to detect inflammation of the one or more joints, the computing device configured to selectively target the detected inflamed one or more joints and actuate the one or more microjet applicators to inject the one or more medicaments to the detected inflamed one or more joints; and a controller configured to report quantity and frequency of dosage of the one or more medicaments.