| 发明名称 | Immunostimulatory compositions and methods | ||
| 摘要 | The invention provides conjugates comprising an immune co-stimulatory polypeptide and an antigen or infectious agent. The conjugates are useful for generating or enhancing an immune response against the antigen or infectious agent. The invention also provides immune cells modified with a conjugate that are useful for generating or enhancing an immune response to an antigen or infectious agent. The invention also provides immunostimulatory moieties comprising an immune co-stimulatory polypeptide that are useful for stimulating an immune response. The invention also provides immunotherapy methods and methods of treating or preventing infections. | ||
| 申请公布号 | US9079976(B2) | 申请公布日期 | 2015.07.14 |
| 申请号 | US201113227162 | 申请日期 | 2011.09.07 |
| 申请人 | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. | 发明人 | Shirwan Haval;Elpek Kutlu G.;Yolcu Esma S. |
| 分类号 | C07K14/70;A61K39/00;A61K45/06;A61K47/48;C12N5/00;A61K39/12;C07K14/705;B82Y5/00;A61K38/00 | 主分类号 | C07K14/70 |
| 代理机构 | Foley & Lardner LLP | 代理人 | Foley & Lardner LLP |
| 主权项 | 1. A combination comprising: (a) a first conjugate comprising (i) a conjugate member comprising an OX40L polypeptide and (ii) a conjugate member comprising a first member of a binding pair; and (b) a second conjugate comprising (i) a conjugate member comprising an antigen and (ii) a conjugate member comprising a second member of said binding pair. | ||
| 地址 | Louisville KY US | ||