Methods of synthesis and purification of heteroaryl compounds

摘要

Provided herein are methods to prepare Heteroaryl Compounds having the following structure:;wherein R1-R4 are as defined herein. The Heteroaryl compounds are useful for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions.

主权项

1. A compound having formula (VIII): or a salt, tautomer or stereoisomer thereof, wherein: each Hal is bromine; R is the alkali metal salt of the carboxylate; and R3 is H, or a substituted or unsubstituted C1-8 alkyl.