发明名称 |
NUCLEASE MEDIATED TARGETING WITH LARGE TARGETING VECTORS |
摘要 |
<p>Compositions and methods are provided for making one or more targeted genetic modifications at a target genomic locus by employing homologous recombination facilitated by single or double- strand break at or near the target genomic locus. Compositions and methods for promoting efficiency of homologous recombination between an LTVEC and a target genomic locus in prokaryotic or eukaryotic cells using engineered nucleases are also provided.</p> |
申请公布号 |
IN9261DEN2014(A) |
申请公布日期 |
2015.07.10 |
申请号 |
IN2014DE09261 |
申请日期 |
2014.11.04 |
申请人 |
REGENERON PHARMACEUTICALS INC. |
发明人 |
FRENDEWEY DAVID;AUERBACH WOJTEK;VALENZUELA DAVID M.;YANCOPOULOS GEORGE D.;NA |
分类号 |
C12N15/85;C07K14/715;C12N15/90 |
主分类号 |
C12N15/85 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|