| 发明名称 |
SUPERKINES AND SYNTHEKINES: REPURPOSED CYTOKINES WITH NEW AND ENHANCED SIGNALING ACTIVITIES |
| 摘要 |
Disclosed herein are IL-4 cytokine compositions with enhanced biological activity having increased selectivity for IL-4 cytokine receptors, and methods for their use. These compositions encompass interleukin-4 (IL-4) muteins. The disclosed methods encompass administering an IL-4 to treat neoplastic diseases, autoimmune diseases, infectious diseases or for expanding a hematopoietic cell population. |
| 申请公布号 |
IN329KON2015(A) |
申请公布日期 |
2015.07.10 |
| 申请号 |
IN2015KOLNP329 |
申请日期 |
2015.02.06 |
| 申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
GARCIA, CHRISTOPHER, K.;BATES,, DARREN L.;MORAGA, IGNACIO |
| 分类号 |
A61K38/20;A61P37/02;C07K14/54 |
主分类号 |
A61K38/20 |
| 代理机构 |
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