ACYCLOVIR LOADED SOLID LIPID NANOPARTICULATE GEL FORMULATION FOR TOPICAL APPLICATION AND METHOD OF FORMULATING THE SAME

摘要

The present invention relates to a method for preparing acyclovir loaded topical solid-lipid nanoparticle (SLN) gel. The method comprises preparing an oil phase by using an antiviral drug, cholesterol, phosphatidyl choline and oleic acid. An aqueous phase is prepared by using surfactants such as Tween 80 and PEG 4000. A nano-emulsion is formed by mixing the oil phase and the aqueous phase at pre- determined conditions of pH and temperature. The method is a hot homogenization method. The present invention also relates to solid-lipid nanoparticles loaded with an antiviral drug, acyclovir. The acyclovir SLN formulation has the ability to avoid the systematic penetration through the skin.