发明名称 |
Composicion de liberacion sostenida inyectable por via intramuscular, que comprende un farmaco, un copolimero biocompatible a base de acido lactico y acido glicolico, con un peso molecular entre 30 y 46 kda y una viscosidad inherente entre 0,25 y 0,31 dl/g, y dmso como disolvente; kit farmaceutico; y metodo para su elaboracion. |
摘要 |
The present invention is directed to an injectable intramuscular depot composition suitable for forming an in situ solid implant in a body, comprising a drug which is risperidone and/or paliperidone or any pharmaceutically acceptable salt thereof in any combination, a biocompatible copolymer based on lactic and glycolic acid having a monomer ratio of lactic to glycolic acid of about 50:50 and a DMSO solvent, wherein the composition releases the drug with an immediate onset of action and continuously for at least 4 weeks and wherein the composition has a pharmacokinetic profile in vivo that makes it suitable to be administered each 4 weeks or even longer periods. |
申请公布号 |
CL2014003216(A1) |
申请公布日期 |
2015.07.10 |
申请号 |
CL20140003216 |
申请日期 |
2014.11.26 |
申请人 |
LABORATORIOS FARMACEUTICOS ROVI S.A. |
发明人 |
GUTIERRO ADURIZ, IBON;FRANCO RODRÍGUEZ, GUILLERMO |
分类号 |
A61K47/34 |
主分类号 |
A61K47/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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