摘要 |
<p>The present invention relates to a process for the preparation of (CF3)2CHOCH2F, said process comprising forming a reaction mixture of (CF3)2CHOCH2CI, potassium fluoride, water and a phase transfer catalyst selected from the group consisting of quarternary ammonium salts, quarternary phosphonium salts, crown ethers, ionic liquids, chiral compounds and high temperature agents such that sevoflurane is formed.</p> |