发明名称 |
USE OF THE ANGIOTENSIN-(1-9) PEPTIDE OR DERIVATIVES THEREOF, USE OF VECTORS OVEREXPRESSING THE ACE2 ENZYME THAT PRODUCES ANGIOTENSIN-(1-9) FOR PREPARING MEDICAMENTS USEFUL FOR PREVENTING, REVERTING, INHIBITING AND/OR REDUCING HYPERTENSION AND/OR INDUCING VASODILATION |
摘要 |
The present invention is related to the use of the angiotensin-(1-9) peptide or peptides derived therefrom, which are biological or chemical analogues, for preparing medicaments useful for preventing, reverting, inhibiting and/or reducing hypertension and/or inducing vasodilation. Furthermore, this invention also comprises a vector overexpressing the homologous angiotensin-II converting enzyme (ACE2) for elevating the concentration in the blood and/or tissues of the angiotensin-(1-9) peptide. This vector may be adenovirus, retrovirus, lentivirus or adeno-associated virus containing the gene encoding for ACE2. This invention allows the administration of angiotensin-(1-9) or the derivatives thereof in oral form, injectable form, continuous infusion pump, or for increasing its levels in the body by means of the combined treatment with angiotensin-I converting enzyme inhibitors, with angiotensin-II receptor antagonists (ARA II), with Rho kinase inhibitors, with renin inhibitors, with L-type calcium channel antagonists and/or with diuretics. |
申请公布号 |
US2015190472(A1) |
申请公布日期 |
2015.07.09 |
申请号 |
US201214390663 |
申请日期 |
2012.04.05 |
申请人 |
Ocaranza Jeraldino María Paz;Jalil Milad Jorge Emilio;Lavandero González Sergio Alejandro;Chiong Lay Mario Martín;Michea Acevedo Luis Fernando |
发明人 |
Ocaranza Jeraldino María Paz;Jalil Milad Jorge Emilio;Lavandero González Sergio Alejandro;Chiong Lay Mario Martín;Michea Acevedo Luis Fernando |
分类号 |
A61K38/22 |
主分类号 |
A61K38/22 |
代理机构 |
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代理人 |
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主权项 |
1. A use of the angiotensin-(1-9) peptide or derivatives of said peptide characterized in that it is for preparing medicaments useful for preventing, reverting, inhibiting and/or reducing hypertension. |
地址 |
Santiago CL |