OX40L FUSION PROTEIN FOR THE IMMUNOTHERAPY OF TUMORS OF VETERINARY ANIMALS

摘要

Provided is an isolated recombinant polypeptide comprising an immunoglobulin domain and a canine OX40L extracellular domain polypeptide fragment or a biological equivalent thereof and compositions comprising: an isolated recombinant polypeptide comprising an immunoglobulin domain and a canine OX40L extracellular domain polypeptide fragment; and a pharmaceutically acceptable carrier. Also provided are methods for treating or ameliorating the symptoms of cancer in a canine comprising administering an effective amount of the isolated recombinant polypeptide of the disclosure and/or a composition of the disclosure to a canine in need thereof.

主权项

1. An isolated recombinant polypeptide comprising an immunoglobulin domain and a canine OX40L extracellular domain polypeptide, wherein the canine OX40L extracellular domain polypeptide comprises from about amino acid 447 to about amino acid 698 of a polypeptide of SEQ ID NO: 2, or about amino acid 332 to about amino acid 464 of a polypeptide of SEQ ID NO: 3, or a biological equivalent of each thereof.