发明名称 DETECTION AND CORRECTION OF JUMPS IN REAL-TIME PCR SIGNALS
摘要 Systems, methods, and apparatuses are provided for detecting and potentially invalidating or correcting jump errors in data from growth processes. A jump error can be identified by determining a second derivative of the data set, and identifying two consecutive cycles with opposite signs in the second derivative. Once a jump error has been detected, the data set can be invalidated or corrected based on various criteria. Whether to invalidate or correct can be based on an absolute jump height, a relative jump height (e.g., relative to the net growth or relative to the baseline), an absolute location (cycle number) of the jump, or a relative location. In one implementation, the jump can be corrected by subtracting a jump height from points subsequent to the jump or by adding the jump height to points prior to the jump.
申请公布号 WO2015101591(A1) 申请公布日期 2015.07.09
申请号 WO2014EP79356 申请日期 2014.12.29
申请人 ROCHE DIAGNOSTICS GMBH;F. HOFFMANN-LA ROCHE AG;ROCHE MOLECULAR SYSTEMS, INC. 发明人 KURNIK, RONALD T.
分类号 G06F19/24 主分类号 G06F19/24
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