发明名称 |
PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS |
摘要 |
Described are ROR? modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating ROR? activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of ROR? activity, for example, autoimmune and/or inflammatory disorders. |
申请公布号 |
CA2936116(A1) |
申请公布日期 |
2015.07.09 |
申请号 |
CA20152936116 |
申请日期 |
2015.01.05 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
DUAN, JINGWU;DHAR, T.G. MURALI;JIANG, BIN;LU, ZHONGHUI;XIAO, HAI-YUN |
分类号 |
C07D403/12;C07D207/12;C07D401/12;C07D401/14;C07D403/04;C07D405/12;C07D407/12;C07D407/14;C07D409/12;C07D413/12;C07D413/14;C07D417/14;C07D471/10;C07D487/04;C07D487/10 |
主分类号 |
C07D403/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|