发明名称 |
PHARMACEUTICAL COMPOSITIONS FOR POORLY WATER-SOLUBLE COMPOUNDS |
摘要 |
This present invention is concerned with novel solid dispersion pharmaceutical compositions for preparation of composition which is comprised of a compound with poor water solubility (a weakly basic, neutral and/or non-ionizable, or a weakly acidic compound), water-soluble polymer(s), pH-sensitive polymer(s) (either enteric polymer or gastric- soluble polymer that is soluble at gastric fluid and insoluble at intestine pH range such as Eudragit E), and/or pharmaceutical acceptable surfactant(s) that would improve the solubility/dissolution of the compound in aqueous media of both low and neutral pHs and provide a relative pH-independent dissolution profile. |
申请公布号 |
CA2935307(A1) |
申请公布日期 |
2015.07.09 |
申请号 |
CA20142935307 |
申请日期 |
2014.12.30 |
申请人 |
ASCENDIA PHARMACEUTICALS, LLC |
发明人 |
HUANG, JINGJUN;TOMINAGA, KAORU;YU, HUI |
分类号 |
A61K9/10;A61K47/30;A61K47/38 |
主分类号 |
A61K9/10 |
代理机构 |
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代理人 |
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主权项 |
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