METHODS AND COMPOSITIONS RELATED TO MUTANT KUNITZ DOMAIN I OF TFPI-2

摘要

Disclosed are methods and compositions relating to plasmin inhibition.

主权项

1. A polypeptide comprising the amino acid sequence set forth in SEQ ID NO:1 or a sequence having at least 79% identity with SEQ ID NO:1, with a leucine to arginine, serine, threonine, asparagine, histidine or lysine substitution at position 17, using BPTI numbering system; wherein the polypeptide inhibits plasmin activity and has decreased anticoagulation activity as compared to a wild type KDI polypeptide.