| 发明名称 |
U1 snRNP Regulates Gene Expression and Modulates Oncogenicity |
| 摘要 |
The present invention relates to the discovery of a novel global gene expression regulation mechanism whereby U1 snRNP (U1) protects pre-mRNAs. In one embodiment, the invention includes compositions and methods for regulating gene expression and treating diseases associated with dysregulated gene expression. |
| 申请公布号 |
US2015191724(A1) |
申请公布日期 |
2015.07.09 |
| 申请号 |
US201314412821 |
申请日期 |
2013.07.05 |
| 申请人 |
The Trustees of the University of Pennsylvania |
发明人 |
Dreyfuss Gideon;Wan Lili;Oh Jung Min;Pinto Anna Maria;Younis Ihab;Berg Michael George;Kaida Daisuke |
| 分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of modulating expression of a gene in a cell, the method comprising contacting a cell with an agent that regulates one or more of U1 snRNP (U1) activity or U1 level, wherein one or more of U1 activity or U1 level is associated with protecting a nascent transcript, permitting modulation of the expression of a gene in a cell. |
| 地址 |
Philadelphia PA US |
