| 摘要 |
The present invention provides an anti-human RANKL antibody, humanized antibody, pharmaceutical compositions and uses thereof. The anti-human RANKL antibody can specifically bind to the amino acid sequence such as SEQ ID NO: 1, its heavy chain comprises the variable region with one of the amino acid sequence shown in SEQ ID NO: 2-9, and the light chain comprises the variable region with one of the amino acid sequence shown in SEQ ID NO: 10-17. Said humanized antibody can bind to human RANKL specifically, the heavy chain variable region is selected from the amino acid sequence shown in SEQ ID NO: 6, 23, 25, 27 or 29, and the light chain variable region is selected from the amino acid sequence shown in SEQ ID NO: 14, 31, 33, 35, 37 or 39. |
