HETEROCYCLIC COMPOUND AND USE THEREOF

摘要

Compounds represented by the formulas;;wherein each symbol is as defined in the specification, and a prodrug thereof have a superior renin inhibitory activity, and are useful as agents for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like.

主权项

1. A compound represented by the formula (I): wherein R1 is a hydrogen atom, an alkyl group optionally having substituent(s), an alkenyl group optionally having substituent(s) or a cycloalkyl group optionally having substituent(s); R2 is (1) a C1-6 alkyl group optionally having 1 to 3 substituents selected from the group consisting of
(a) a hydroxyl group,(b) a halogen atom,(c) a C1-6 alkoxy group,(d) a C1-6 alkyl-carbonyloxy group, and(e) a C3-10 cycloalkyl group, (2) a carboxy group, (3) a C1-6 alkoxy-carbonyl group, (4) a C1-6 alkyl-carbonyl group, or (5) a group represented by the formula: —CO—NR′R″ wherein R′ and R″ are each a hydrogen atom; X is (1) a hydrogen atom; (2) a C1-6 alkyl group optionally substituted by 1 to 3 substituents selected from the group consisting of
(a) a halogen atom,(b) a hydroxyl group,(c) a C1-6 alkoxy group optionally having a C1-6 alkoxy group or a halogen atom,(d) a C1-6 alkylthio group,(e) an aryl group,(f) an aryloxy group optionally having a C1-6 alkoxy group or a halogen atom, and(g) a heteroaryl group; or (3) a C3-10 cycloalkyl group; and ring A is benzimidazole, or a salt thereof.