| 摘要 |
Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I):;;or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle. |
| 主权项 |
1. A compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein:
X1 is —F, —Cl, —CF3, —CN, or CH3;X2 is —H, —F, or —Cl;Z1 is N or CH;Z2 is N or CR0;Z3 is CH or N;Y is —C(R4R5)—[C(R6R7)]n-Q or —C(R4)═C(R6)-Q;R0 is —H, —F, or CN;R1, R2, and R3 are each and independently —CH3, —CH2F, —CF3, —C2H5, —CH2CH2F, —CH2CF3; or optionally R2 and R3, or R1, R2 and R3, together with the carbon atom to which they are attached, form a 3-10 membered carbocyclic ring;R4 and R5 are each and independently —H;R6 and R7 are each and independently —H, —OH, —CH3, or —CF3; oroptionally, R5 and R7 together with the carbon atoms to which they are attached form a cyclopropane ring; andeach Q is independently —C(O)OR, —OH, —CH2OH, —S(O)R′, —P(O)(OH)2, —S(O)2R′, —S(O)2—NR″R′″, or a 5-membered heterocycle selected from the group consisting of: JQ is —H, —OH or —CH2OH;R is —H or C1-4 alkyl;R′ is —OH, C1-4 alkyl, or —CH2C(O)OH;R″ is —H or —CH3;R′″ is —H, a 3-6 membered carbocyclic ring, or C1-4 alkyl optionally substituted with one or more substituents selected from the group consisting of halogen, —ORa and —C(O)ORa;Ra is —H or C1-4 alkyl; andn is 0 or 1. |
