发明名称 |
COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF OVARIAN CANCERS THAT ARE ASSOCIATED WITH REDUCED SMARCA4 GENE EXPRESSION OR PROTEIN FUNCTION |
摘要 |
Provided are compositions and methods for the identification and treatment of ovarian cancers, such as small cell ovarian cancers, in particular small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), which ovarian cancers are characterized by reduced SMARCA4 gene expression and/or protein function and, as a consequence, are sensitive to growth and/or survival inhibition by one or more compounds that restore SMARCA4 gene expression and/or protein function. |
申请公布号 |
WO2015103431(A1) |
申请公布日期 |
2015.07.09 |
申请号 |
WO2014US73077 |
申请日期 |
2014.12.31 |
申请人 |
MEMORIAL SLOAN-KETTERING CANCER CENTER |
发明人 |
LEVINE, DOUGLAS, A.;BERGER, MICHAEL, F.;SOSLOW, ROBERT, A.;JELINIC, PETAR |
分类号 |
C12Q1/68;A61K31/7088;A61K38/00 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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地址 |
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