发明名称 |
HETEROATOM CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS |
摘要 |
Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions in a method of treating cancer. The dUTPase inhibitors disclosed contain a uracil isostere in the molecule represented by a 2,6-diketopiperazine moiety. Thioanalogs of the uracil isostere where a thione replaces each of the ketone are also disclosed. |
申请公布号 |
CA2935717(A1) |
申请公布日期 |
2015.07.09 |
申请号 |
CA20152935717 |
申请日期 |
2015.01.02 |
申请人 |
UNIVERSITY OF SOUTHERN CALIFORNIA |
发明人 |
LADNER, ROBERT D.;GIETHLEN, BRUNO |
分类号 |
C07D403/06;A61K31/496;A61K31/5377;A61P35/00;C07D413/06;G01N33/48 |
主分类号 |
C07D403/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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