发明名称 |
METHODS AND SYSTEMS FOR THE ELECTROCHEMICAL DETECTION OF ANALYTES |
摘要 |
Methods and devices electrochemically detect analytes. The methods employ metal particles conjugated to the analytes. The metal particles can serve as an electrochemical label for the analyte to which they are conjugated. The metal particles can be oxidized to form metal ions that can subsequently be electrochemically detected and/or quantified. The metal ions can be electrodeposited as metal on a working electrode. The potential applied at the working electrode can then be varied to reoxidize the deposited metal to metal ions. The intensity of the resulting voltammetric peak reflects the amount of metal deposited on the working electrode, and therefore the amount of metal nanoparticle label and analyte. Sensitivity can tie improved by selectively localizing the analyte-metal particle conjugate in the vicinity of the working electrode. Analytes can be detected at concentrations as low as 767 fM via anodic stripping voltammetry, with no washing steps or electrode modifications. |
申请公布号 |
CA2935850(A1) |
申请公布日期 |
2015.07.09 |
申请号 |
CA20142935850 |
申请日期 |
2014.12.19 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
CROOKS, RICHARD M.;SCIDA, KAREN;CUNNINGHAM, JOSEPHINE |
分类号 |
G01N27/416;G01N33/487 |
主分类号 |
G01N27/416 |
代理机构 |
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代理人 |
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地址 |
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