| 主权项 |
1. A compound, or a salt thereof, according to the formula (I) Wherein A is a group selected from: Wherein m is an integer of between 0 and 2p+4; p is 0, 1, 2, or 3;
Z1 is C(R1) or N;Z2 is C(R2) or N;Z3 is C(R3) or N, wherein at least one of Z1, Z2 or Z3 is not N;R1 is selected from the group consisting of hydrogen, halogen, C1-C6alkyl, C1-C6alkoxy, haloC-C6alkyl, haloC-C6alkoxy C1-C6alkoxycarbonyl, CO2H and C(O)NRARB;R2 and R3 are independently selected from the group consisting of hydrogen, halogen, hydroxy, NRCRD, cyano, CO2H, CONRARB, SO2C1-C6alkyl, and SO2NH2, SO2NRARB, C1-C6alkoxycarbonyl, —C(NRA)NRCRD, C1-C6alkyl, haloC1-C6alkyl, C2-C6alkenyl, C1-C6alkoxy, haloC1-C6alkoxy, C2-C6alkenyloxy, wherein each alkyl, alkenyl, alkoxy and alkenyloxy is unsubstituted or substituted with up to 4 substitutents independently selected from halogen, hydroxy, cyano, tetrazole, C1-C4alkoxy, C1-C4haloalkoxy, CO2H, C1-C6alkoxycarbonyl, C(O)NRARB, NRCRD, optionally substituted phenyl, heterocycle having 4 to 7 ring atoms and 1, 2, or 3 ring heteroatoms selected from N, O or S, optionally substituted heteroaryl having 5 or 6 ring atoms and 1, 2 or 3 ring heteroatoms selected from N, O or S, and wherein optional phenyl and optional heteroaryl substituents are selected from halogen, hydroxy, C1-C4alkyl, C1-C4alkoxy and CO2H;R4 is selected from the group consisting of hydrogen, halogen, and C1-C6alkyl;R5 is C1-C4alkyl, hydroxyC1-C4alkyl, C1-C4alkoxyC1-C4alkyl, haloC1-C4alkyl, amino, methylamino;X1 is CR9R22 or sulfur;X2 is CR7R8, oxygen, sulfur, N(H) or N(C1-C6alkyl), wherein at least one of X1 and X2 is carbon; orX1 and X2, in combination, forms an olefin of the formula —C(R7)═C(H)— or —C(R7)═C(C1-C4alkyl)-, wherein the C(R7) is attached to X3;X3 is (CR6R21)q or N(H) wherein q is 0, 1 or 2, wherein X3 is CR6R21 or (CR6R21)2 when either X1 or X2 is sulfur or X2 is oxygen; orX2 and X3, taken in combination, are —N═C(H)— or —N═C(C1-C4alkyl)- in which the C(H) or C(C1-C4alkyl) is attached to X1;R6 is selected from the group consisting of hydrogen and C1-C6alkyl;R7 is hydrogen, halogen, hydroxy, cyano, C1-C6alkyl, C1-C6alkoxy, hydroxyC1-C6alkyl, C1-C6alkoxyC1-C6alkyl, haloC1-C6alkyl, or C1-C6haloalkoxy;R8 is hydrogen, halogen, hydroxy, azide, cyano, COOH, C1-C6alkoxycarbonyl, C1-C6alkyl, C1-C6alkoxy, C1-C6haloalkyl, C1-C6haloalkoxy, NRARB, N(H)C(O)C1-C6alkyl, hydroxyC1-C6alkyl, C1-C6alkoxyC1-C6alkyl, or C1-C6alkyl substituted with NRARB, N(H)C(O)H or N(H)C(O)(C1-C4alkyl);R9 is selected from the group consisting of hydrogen, hydroxy, halogen, C1-C6alkyl, haloC1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6alkoxy, haloC1-C6alkoxy, NRARB, N(H)C(O)C1-C6alkyl, N(H)C(O)OC1-C6alkyl and OC(O)NRCRD each of alkyl, alkoxy, alkenyl, and alkynyl substituents may be substituted with 0, 1, or 2 groups independently selected at each occurrence from the group consisting of halogen, hydroxy, C1-C6alkyl, C1-C6alkoxy, and NRARB;R20 is hydrogen or C1-C6alkyl;R21 is selected from the group consisting of hydrogen, phenyl and C1-C6alkyl, which alkyl group is unsubstituted or substituted with hydroxy, amino, azide, and NHC(O)C1-C6alkyl;R22 is selected from the group consisting of hydrogen, halogen, hydroxy, amino and C1-C6alkyl;CR7R8, taken in combination forms a spirocyclic 3 to 6 membered carbocycle which is substituted with 0, 1, or 2 substituents independently selected from the group consisting of halogen and methyl; orR7 and R8, taken in combination, form an exocyclic methylidene (═CH2);R7 and R22 or R8 and R9, taken in combination form an epoxide ring or a 3 to 6 membered carbocyclic ring system which carbocyclic ring is substituted with 0, 1, or 2 substituents independently selected from the group consisting of halogen, methyl, ethyl, hydroxyC1-C4alkyl, C1-C6alkoxyC1-C4alkyl, C1-C4alkoxycarbonyl, CO2H, and C1-C4alkyl substituted with NRARB;R6 and R7 or R8 and R21, taken in combination, form a fused 3 membered carbocyclic ring system which is substituted with 0, 1, or 2 substituents independently selected from the group consisting of halogen, methyl, ethyl, hydroxyC1-C4alkyl, C1-C6alkoxyC1-C4alkyl, C1-C4alkoxycarbonyl, CO2H, and C1-C4alkyl substituted with NRARB; orR20 and R22 taken in combination form a fused 3 carbocyclic ring system;R9 and R21 taken in combination form a form 1 to 3 carbon alkylene linker;R7 and R20 taken in combination form 1 to 3 carbon alkylene linker;R10 is hydrogen, C1-C4alkyl, haloC1-C4alkyl, hydroxyC1-C4alkyl or C1-C4alkoxyC1-C4alkyl;R11 is hydrogen or C1-C4alkyl; orCR10R11, taken in combination, form a geminal cyclopropyl ring; R12 is independently selected at each occurrence from the group consisting of hydrogen, halogen, and C1-C4alkyl;
R13 is independently selected at each occurrence from the group consisting of C1-C4alkyl, halogen, haloC1-C4alkyl, or two geminal R13, together form a spiroC3-C6cycloalkyl, or two vicinal R13 form a double bond;RA and RB, are each independently selected from the group consisting of hydrogen and C1-C6alkyl, haloC1-C6alkyl, C1-C6alkoxyC1-C6alkyl, or hydroxyC1-C6alkyl; and RC and RD are independently selected from the group consisting of hydrogen, and C1-C6alkyl, haloC1-C6alkyl, C1-C6alkoxyC1-C6alkyl, hydroxyC1-C6alkyl, or NRCRD, taken in combination, form a heterocycle having 4 to 7 ring atoms and 0 or 1 additional ring N, O or S atoms, which heterocycle is substituted with 0, 1 or 2 substituents independently selected from the group consisting of C1-C4alkyl, halogen, hydroxy, C1-C4alkoxy. |
